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Superior vena cava (SVC) syndrome is a medical emergency not an uncommonly observed occurrence in patients with malignancy malignanciesand it is often described as a medical emergency. 1 In most majority of the cases, SVC syndrome it occurs due to the mechanical obstruction of blood flow through the SVC by extraluminal compression with caused by a primary intrathoracic malignanciestumor. However, intraluminal obstruction due to thrombosis can result in intraluminal obstruction in some cases, can also produceleading to the symptoms and signs of SVC syndrome. Clot-related SVC obstruction syndrome due to thrombosis  2 is mostly associated with indwelling central venous catheters and or pacemaker leads, although such this type of thrombosis can occur spontaneously in a background of aunder hypercoagulable stateconditions, such as, e.g., those associated with malignanciesy. Here, anWe present an unusual case of sudden- onset SVC syndrome has been reported, which on initial radiologic evaluation in which the initial radiological evaluation was found to have ashowed a lung nodule without any significant mediastinal mass or adenopathy compressing the SVC. Subsequent investigation with by Doppler ultrasonography of the neck showed revealed thrombosis in the right internal jugular, right subclavian, and 3 right brachiocephalic veins, which was responsible for caused SVC syndrome. Histopathological evaluation of the lung nodule confirmed the presence of an adenocarcinoma. Therefore,This case highlights that venous thromboembolism as a paraneoplastic syndrome should be kept in mind considered as a paraneoplastic syndrome while when evaluating a case of SVC obstructions in a cancer patients. Management of the underlying disease is of prime very importantce in such cases, and anticoagulation is the mainstay of therapy. Ability The ability to identify diagnose paraneoplastic syndromes may have a significantly effect impact on clinical outcomes, by ranging fromcontributing to early diagnosis, leading to earlier treatment and to potentially improved quality of life of the patients002E

Explanations

Superior vena cava (SVC) syndrome is not an uncommonly observed occurrence in patients with malignancy malignancies , and 1 it is often described as a medical emergency. In most majority of the cases, SVC syndrome occurs due to mechanical obstruction of the SVC by extraluminal compression with caused by a primary intrathoracic malignanciestumor. However, intraluminal obstruction due to thrombosis can also produce result in symptoms and signs of SVC syndrome. Clot-related SVC obstruction syndrome due to thrombosis  2is mostly associated with indwelling central venous catheters and or pacemaker leads, although such this type of thrombosis can occur spontaneously in a background of aunder hypercoagulable stateconditions, such as, e.g., those associated with malignanciesy. Here, an unusual case of sudden- onset SVC syndrome has been reported, in which the on initial radiological evaluation was found to have ashowed a lung nodule without any significant mediastinal mass or adenopathy compressing the SVC. Subsequent investigation with Doppler ultrasonography of the neck showed thrombosis in the right internal jugular, right subclavian, and 3 and right brachiocephalic veins, which was responsible for SVC syndrome. Histopathological evaluation of the lung nodule confirmed the presence of an adenocarcinoma. Therefore, venous thromboembolism as a paraneoplastic syndrome should be kept in mind considered while when evaluating a case of SVC obstructions in a cancer patients. Management of the underlying disease is of prime importance in such cases, and anticoagulation is the mainstay of therapy. Ability The ability to identify diagnose paraneoplastic syndromes may have a significant effect on clinical outcomes, by ranging fromcontributing to early diagnosis, leading to earlier treatment and to potentially improved quality of life of the patient.

Explanations

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