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To dateCurrently, there is growing number of there are several well-known predictors of malignancy of the thyroid nodule malignancys; these include including a solid, fixed formation tumors that is are detected by on physiological examination, rapid growth, and large sizeenlargement of the site, tracheostomy, dysphagia, or lymphadenopathy, history of irradiation with in the history of low doses of radiation toof the head and neck during infancy, age less for <20 years and or more than >70 years, and male gender. Detection Timely detection of thyroid tumors, that are characterized by a benign course and favorable prognosis, can significantly reduce the number of surgical interventions required. However, in somethere are cases, where the malignant potential of malignancy of the tumor cannotcan not be determined and. In this case, alternative diagnostic methods are required. These such as those mayinvolving include the detection of BRAF and RAS spot point mutations and, PAX8/ / PPAR γ? and RET/ / PTC translocations are required.  1 However, , but given the high cost of genetic testingresearch data and relatively low sensitivity, these methods are not always suitable for routine diagnostics. DeterminationThe determination of the level of serum hormone levelshormones may be cheaper more cost-effective and yield faster results. This review is devoted to the assessesment of the role ofcurrent concept on thyroid- stimulating hormone (TSH) role in the development and progression of differentiated thyroid cancer, namely papillary thyroid carcinoma. Numerous studies have demonstrated reported the significance of high (TSH) level in the malignization of thyroid nodulesnodes malignisation and disease progression associated with rapid growth, aggressiveness, and metastasis development.. Many authors have found TSH levelfind this test to be useful for distinguishing between benign and malignant thyroid tumors and have suggested that it may can  2 be used as an auxiliary diagnostic biomarker for thyroid tumors.in the diagnostics. However, 3 there some authors havewho did not fouind any no relationship correlation between TSH level and thyroid cancer. Finally, there is a growing body of investigations evidence on opposing associationsdemonstrating the opposite relations between TSH levels and thyroid malignanciescancers. Nevertheless, some geneticGenetic studies support also are in favor of the presence of a reciprocal association between TSHthe levels of TSH and the development of thyroid cancer development.

Explanations

To dateCurrently, there is a growing number of well-known predictors of malignancy of the thyroid nodule malignanciess, including a solid, fixed formation tumors that is are detected by on physiological examination, rapid growth, and large size of the site, tracheostomy, dysphagia, or lymphadenopathy, history of irradiation with in the history of low doses of radiation toof the head and neck during infancy, age less for than 20 years and or more greater than 70 years, and 1 male gender. Detection of thyroid tumors, that are characterized by a benign course and favorable prognosis, can significantly reduce the number of surgical interventions. However, there are in some cases, where the malignant potential of malignancy of the tumor cannotcan not be determined. In such casesthis case, alternative diagnostic methods are required. These may include the detection of BRAF and RAS spot point mutations and, PAX8/ / PPAR γ? and RET/ / PTC translocations, . but However, given the high cost of genetic testingresearch data and the relatively low sensitivity, these methods are not always suitable for routine diagnostics. The dDetermination of the level of serum hormones may be cheaper and yield faster results. This review is devoted toinvolves the assessment of the role ofcurrent concept on thyroid- stimulating hormone (TSH) role in the development and progression of differentiated thyroid cancercarcinoma, namely papillary thyroid carcinoma. Numerous studies have demonstrated the significance of high (TSH) level in thyroid nodules malignizsation and disease progression associated with rapid growth, aggressiveness, and metastasis development.. Many authors have found TSH levelfind this test to be useful for distinguishing between benign and malignant thyroid tumors and have suggestedthat it may can 2 be used as an auxiliary in the diagnostics. However, 3 there have been some authors who did not find found any no relationship between TSH level and thyroid cancer. Finally, there is a growing body of investigations evidence demonstrating the opposite relations association between TSH levels and thyroid malignanciescancer. Nevertheless, Ggenetic studies support also are in favor of the presence of a reciprocal association between TSHthe level of TSH and the development of thyroid cancer development.

Explanations

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