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Corneal dystrophies are a group of diverse bilateral genetic and non-inflammatory diseases limited to the cornea. These diseases are often characterized by the accumulation of abnormal material in the cornea.  1 Clinically, it these diseases is  2 are categorized into three groups,; namely superficial corneal dystrophy, corneal stromal dystrophy, and posterior corneal dystrophy;, which these groups are further subcategorized into other classes. One Macular corneal dystrophy (MCD) is a subcategory of corneal stromal dystrophiesdystrophy is macular corneal dystrophy (MCD),. which is characterized by bilateral cloudy regions within a hazy stroma, eventually leading to severe visual impairment. Mutation in the carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 (CHST6) gene is typically usually responsible for MCD. However, it is also caused by other factors, and all MCD cases of MCD cannot be explained by mutations in the CHST6 coding region, deletion/ or replacement in the upstream region, or mutations in splice sites resulting that result in loss of splicing signal loss.

Retinitis pigmentosa (RP) is a disease with that causes a variety ofvarious disorders. Some patients show symptoms of vision loss of vision during childhood, while whereas some others live without do not show any symptoms until their middle age. Most cases patients present with classical symptoms such as night blindness (nyctalopia) and of difficultiesy with in adapting to darkness and night blindness (nyctalopia) in old age and loss of vision in early adolescence. Following theWith advanced disease progression, patientsthey lose their distant peripheral vision, 3 develop tunnel vision, and finally lose their central vision, which usually occurs at around the age of sixty60 years of age. The reduction of in ROD and CONErod and cone photoreceptors is similar among in other types of RP disorders. Sometimes, the decrease in CONE cones is greater than that in ROD rods, which is then called cone - 4rod degeneration, a form of RP in which the loss of vision and defects in color vision are the predominant initial symptoms.

Explanations

Corneal dystrophies are a group of diverse bilateral genetic and non-inflammatory diseases limited to the cornea. Clinically, it is these diseases are categorized into three groups;, namely superficial corneal dystrophy, corneal stromal dystrophy, and posterior corneal dystrophy, which are further subcategorized into other classes. 1 . Macular corneal dystrophy (MCD) is a subcategory of corneal stromal dystrophiesdystrophy. Mutation in the  2 carbohydrate (N-acetylglucosamine6acetylglucosamine 6-O) sulfotransferase 6 (CHST6) gene is usually responsible for MCD. However, all MCD cases cannot be explained by mutations in the CHST6 coding region, deletion/ or replacement in the upstream region, or mutations in splice sites resulting in loss of splicing signal loss.

RP is a disease with a variety ofthat causes various disorders. Some patients show symptoms of loss of vision loss during childhood while some, whereas others live withoutdo not show any symptoms until their middle age. Most casespatients present classicalwith classic symptoms of difficulties, such as difficulty with in adapting to darkness and night blindness (nyctalopia)) in oldageold age and as well as loss of vision in early adolescence. Following theWith disease progression, they patients lose their distant peripheral vision, develop tunnel vision,  3 and finally lose their central vision, which usually occurs at the agearound 60 years of sixtyage. The reduction of RODin rod and CONE cone photoreceptors  4 is similar inamong other types. of RP disorders. Sometimes, the decrease in CONEcones is greater than that in RODrods, which is then called cone - 5 rod degeneration, a form of RP in which the loss of vision and defects in color vision are the predominant initial symptoms.

Explanations

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