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What came first: the DNA or protein? Discovery The discovery of ribozymes and the RNA world hypothesis of RNA world hashave provided a new perspective to given this question another dimension. Enzymes were was the only known natural catalysts to the discovery of ribozymes.

Ribozymes (also known as RNA enzyme enzymes or catalytic RNA) are RNA particles that catalyze biochemic biochemical reactionreactions. Thomas Cech and Altman, who were the first to discover discovered ribozymes during in the 1980s, and went on later to investigate subsequently studied their the catalytic properties. Thomas Cech found that when additional cell extract was absent, the splicing of introns in a ribosomal RNA in ribosomal RNA gene genes in Tetrahymena thermophila were found to occur in Tetrahymena thermophila underwent splicingin the absence of additional cell extract. Sidney Altman and his colleagueset al., 1 separated discovered the bacterial RNase P, an enzyme responsible for changing converting a precursor tRNA to its active tRNAform. However, it was found that in addition to the proteins, the enzyme also contained RNA that could stimulate the cleavage of the cleavage of precursor tRNA into tRNA in the absence of the protein component. Also, Thomas Cech gave the conclusion concluded that the intron sequence of the RNA cancould break cleave and reform phosphodiesterphosdiester bonds. They Cech and Altman won the Nobel Prize in chemistry for the same thing this in 1989. Natural ribosomes ribozymes  2 catalyze the hydrolysis of their own phosphodiester bonds. They also catalyze and other RNA sequences. They also catalyze the aminotransferase activity. They also catalyze the hydrolysis of the other RNA. Ribozymes are so called because they act as enzymes in terms of their specificity and belong to RNA.  3 HoweverDespite possessing enzymatic activity, they ribozymes are different differ from other enzymes because of thbecause of the e following reasons:

1)      Unlike enzymes, ribozymes do not require a specific pH and temperature to function.

2)      Ribozymes consists They consist of nucleotides.

3)      They do not have well defined well-defined  4 regions, such as active site and catalyzed catalytic sitesites.

4)      They can act on a veryextremely small amounts of substances but perform a more limited set of instructions.

To date, A many number of natural ribozymes have been discovered and several artificial ribozymes have been synthesized till date. The discovery of naturally occurring ribozymes is increasing, along with which several artificial ribozymes have also been synthesized. Due to Because of their abilities, ribozymes have been investigated for applications as therapeutic agents and, biosensors, and in genomics functions in addition to their functions in genomics and gene discoveryand discovery of genes.

Explanations

What came first: the DNA or protein? Discovery The discovery of ribozymes and the hypothesis of the RNA world hahaves given this question another dimension. Enzymes was were the only known natural catalysts to the discovery of ribozymes.

Ribozymes (also known as RNA enzyme enzymes or catalytic RNA) are RNA particles that catalyze biochemic biochemical reactionreactions. Thomas Cech and Sidney Altman were the first to discover ribozymes during the 1980s and later went on later to investigate their the catalytic properties. Thomas Cech found that splicing of introns in a ribosomal RNA in the ribosomal RNA gene in Tetrahymena thermophila were found to occurred in the absence of additional cell extracts. Sidney Altman and his colleagues, 1 separated discovered the bacterial RNase P, an enzyme responsible for changing a precursor to active tRNA. However, it was found that in addition to the proteins, the enzyme also contained RNA that could stimulate the cleavage of precursor tRNA into tRNA in the absence of the protein component. AlsoIn addition, Thomas Cech gave reached the conclusion that the intron sequence of the RNA cancould break and reform phosphodiesterphosdiester bonds. They won the Nobel Prize in chemistry for the same thing in 1989. Natural ribosomes ribozymes  2catalyze the hydrolysis of their own phosphodiester bonds. They also catalyze the aminotransferase activity. They Further, they also catalyze the hydrolysis of the other RNA. They are termed as Ribozymes ribozymesare so called because they act are as specific as enzymes in terms of their specificity and belong to RNA. However, they are different from enzymes because of the following reasons:

1)      Unlike enzymes, ribozymes do not require a specific pH and temperature.

2)      Ribozymes consists 3of nucleotides.

3)      They do not have well- defined  4 regions, such as active site and catalyzed catalytic sites.

4)      They can act on a very small amounts of substances but perform a more limited set of instructionsactions.

MA any number of ribozymes have been discovered till date. The discovery of naturally occurring ribozymes is increasing, along with which the synthesis of several artificial ribozymes have also been synthesized. Due to Because of their abilities, ribozymes have been investigated for applications as therapeutic agents and, biosensors, as well as and in genomics functions and discovery of genes.

Explanations

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