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Cases in whichOnly three previous reports have shown that human parvovirus B19 (HPV B19) can induce aplastic crisis and unmask the hereditary spherocytosis (HS) in a family are rare, with only three cases being reported so far . In 1984Previously, some researches in 1984 reported an adult sibling pair with HS who was reported to developed aplastic crisis after a febrile illness that was , which was further diagnosed as to be HPV B19 infection . The diagnosis of HPV B19 was developed based on the presence of specific IgM antibodiesy in their sera, as PCR polymerase chain reaction was not availablecould not be performed.  1 They also found that the The children of one of the patients also developed HPV B19 -induced aplastic crisis, which was resolved with supportive care. These two adult patients were treated withby blood transfusions and supportive care and were discharged after 6- 2 8 days of hospitalization care. Similarly, in 1987, In a similar report, McLellan and Rutter in 1987 reported HPV B19 -induced aplastic crisis was reported in two teenage sisters, which led leading to the diagnosis of HS. They both presented with progressive fatigue, dizziness, and pallor after a febrile illness. In addition, their mother They also had a history of splenectomy in their mother at the age of 11 years. They both were diagnosed with to have HPV B19; and they underwent splenectomy and received supportive care until recovery. In 1962, Chanarin et al. reported aplastic crisis was reported in three 3 members of a family (two2 sisters and their father).9 One of the sisters The (10- years -old) girl presented with a 7 - 3 days history of fever of unknown origin, jaundice, and dark urine. The same illness symptoms was were noted reported in the other sister (2- years -old) sister and the father (32- years -old), father who both had HS. The elder sister 10-year-old girl was treated with repeated transfusions, splenectomy, and supportive care for 92 days.

Explanations

Only three previous reports have shown that HPV B19 can induce aplastic crisis and unmask the HS in a family. PreviouslyIn 1984, some researchers in 1984 reported an adult sibling pair with HS who developed aplastic crisis after a febrile illness, which was further diagnosed as to be HPV B19 infection. The diagnosis of HPV B19 was developed made based on the basis of specific IgM antibodiesy in their sera, as PCR was not available. They also found that the The children of one of the patients also developed HPV B19 -induced aplastic crisis, which was resolved with supportive care. These two adult patients were treated by with blood transfusion and supportive care and were discharged after 6- 18 days of hospitalization care. In a similar report in 1987, McLellan and Rutter in 1987 reported HPV B19 -induced aplastic crisis in two teenage sisters, which led leading to the diagnosis of HS. They both presented with progressive fatigue, dizziness , 2 and pallor after a febrile illness. Their mother They also had a history of splenectomy in their mother at the age of 11 years. They both were both diagnosed with to have HPV B19 and underwent splenectomy and received supportive care until recovery. In 1962, Chanarin et al. reported aplastic crisis in three 3 members of a family (two2 sisters and the father). The 10-year-old girl sister presented with a 7 - 3days history of fever of unknown origin, jaundice, and dark urine. The same illness was reported in the 2-year-old sister and 32-year-old father, who both had HS. The 10-year-old girl sister was treated with repeated transfusions, splenectomy, and supportive care for 92 days.

Explanations

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