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Wheezing Bronchial asthma mainly manifests as wheezing and shortness of breath are main symptoms of bronchial 1 . Patients with asthma. Asthmatics  2 showedshow increased superoxide generation from leuckocytes, as well as and increased lipid peroxidation product, indicating products, both of which indicate increased oxidative stress. Ascorbic acid is an important antioxidant which that directly neutralizes free radicals,; thus therefore, it is continuously usually utilizedused to maintain thea redox state in the lungs of lung inpatients with asthma. According to Hatch et al suggested that ., ascorbic acid is the major antioxidant substance present in the airway surface lining of the lung,lungs and may protect against endogenous as well asand exogenous oxidants. OurW present finding ofe found that the presence of a low ascorbic acid level in wheezing children couldwith wheezing may be attributed to its normal physiological function and, elevatedincreased utilization to overcome the continuous generation of oxidant radicals and also and to neutralize the exogenous oxidant. It has been suggested thatoxidants. Therefore, 3 ascorbic acid deficiency may be either an underlying factor in the pathophysiology of asthma or a a response to asthmatic airwaysairway inflammation. Our in patients with asthma. Consistent with our findings of , other studies have also reported a low ascorbic acid level in wheezing children with wheezing is in agreement with the earlier reports of; these researchers have who attributed such kind of loweringthe decrease in the plasma ascorbic acid level in plasma to its normal physiological function i.e., its utilizationfunctions in maintaining the maintenance ofbody’s defense mechanism, tissue and in the integrity and, replacement, and healing process.processes of tissues. Destruction of the respiratory mucous membrane during common cold and resulting reduction of the consequent decrease in tissue ascorbic acid, levels may further delay in the healing of the mucous membrane surface leading and result in to prolonged asthma symptoms of asthma. A study shows that reported decreased serum levels of antioxidant vitamins are decreased in the sera of asthmatic patients with asthma, even during the asymptomatic periodsperiod of the disease, and thus. Therefore, this decrease is does not totally dependentcompletely depend on the increased oxidative stress, as reflected by lipid peroxidation products.

Explanations

Wheezing and shortness of breath are the main symptoms of bronchial asthma. Patients with Aasthmatics  2 showed increased superoxide generation from leuckocytes, as well as and increased lipid peroxidation  products, both of which indicateing increased oxidative stress. Ascorbic acid is an important antioxidant which that directly neutralizes free radical, thusradicals; therefore, it is continuously utilizedused to maintain thea redox state in the of lungs of inpatients with asthma. Hatch et al. suggested that ascorbic acid is the major antioxidant substance present in the airway surface lining of the lungs, and may protects against endogenous as well asand exogenous oxidants. Our present finding of a low ascorbic acid level in wheezing children couldwith wheezing may be attributeddue to its normal physiological function and, elevatedincreased utilization to overcome the continuous generation of oxidant radicals and also and to neutralize the exogenous oxidants. It has been suggested that Therefore, 3 ascorbic acid deficiency may be either an underlying factor in the pathophysiology of asthma or a response to asthmatic airwaysairway inflammation. Our findings of low ascorbic acid levels in wheezing children with wheezing is are in agreement with the earlier reports, wherein of researchers who attributed such kind of loweringthe decrease in the plasma ascorbic acid level in plasma to its normal physiological functions, i.e., its utilization including its roles in maintaining the maintenance ofbody’s defense mechanism, tissue and in the integrity and, replacement, and healing process.processes of tissues. Destruction of the respiratory mucous membrane during common cold and the consequent resulting reduction of the in the tissue ascorbic acid, level may further delay in the healing of the mucous membrane surface, leading to prolonged symptoms of asthma. A study reported shows that serum levels of antioxidant vitamins are decreased in the sera of asthmatic patients with asthma, even during the asymptomatic periods of the disease, and thus. Therefore, this decrease is does not completely totally dependent on the increased oxidative stress, as reflected by lipid peroxidation products.

Explanations

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